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Eukaryotic cold shock domain proteins: highly versatile regulators of gene expression

Authors

  • Marija Mihailovich,

    1. Gene Regulation Programme, Centre de Regulació Genòmica (CRG-UPF), Barcelona, Spain
    2. Present address: Proteomics and Functional Genomics, Department of Experimental Oncology, European Institute of Oncology, Via Adamello 16, 20139 Milano, Italy
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  • Cristina Militti,

    1. Gene Regulation Programme, Centre de Regulació Genòmica (CRG-UPF), Barcelona, Spain
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  • Toni Gabaldón,

    1. Bioinformatics Programme, Centre de Regulació Genòmica (CRG-UPF), Barcelona, Spain
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  • Fátima Gebauer

    Corresponding author
    1. Gene Regulation Programme, Centre de Regulació Genòmica (CRG-UPF), Barcelona, Spain
    • Gene Regulation Programme, Centre de Regulació Genòmica (CRG-UPF), Dr. Aiguader 88, 08003 Barcelona, Spain.
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Abstract

Cold shock domain (CSD)-containing proteins have been found in all three domains of life and function in a variety of processes that are related, for the most part, to post-transcriptional gene regulation. The CSD is an ancient β-barrel fold that serves to bind nucleic acids. The CSD is structurally and functionally similar to the S1 domain, a fold with otherwise unrelated primary sequence. The flexibility of the CSD/S1 domain for RNA recognition confers an enormous functional versatility to the proteins that contain them. This review summarizes the current knowledge on eukaryotic CSD/S1 domain-containing proteins with a special emphasis on UNR (upstream of N-ras), a member of this family with multiple copies of the CSD.

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