RNAi in X inactivation: contrasting findings on the role of interference

Authors

  • Satya K. Kota

    Corresponding author
    1. Institute of Molecular Genetics, CNRS, UMR5535, 1919 Route de Mende, 34293 Montpelier Cedex 5, France
    • Institute of Molecular Genetics, CNRS, UMR5535, 1919 Route de Mende, 34293 Montpelier Cedex 5, France.
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Abstract

X inactivation is the process that brings about the dosage equivalence of X-linked genes in females to that of males. This complex process initiated at a very early stage of female embryonic development is orchestrated by long non-coding RNAs transcribed in both sense and antisense orientation. Recent studies present contradicting evidence for the role of small RNAs and RNase III enzyme Dicer in the X inactivation process. In this review, I discuss these results in the overall perspective of X inactivation and gene silencing.

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