- Top of page
- Interlink between Xi establishment and Dicer
- No role for Dicer in Xist and H3K27 recruitment on to Xi
- Proper Xist localization in Dicer-deficient embryos
- Conclusion and future perspectives
X inactivation is the process that brings about the dosage equivalence of X-linked genes in females to that of males. This complex process initiated at a very early stage of female embryonic development is orchestrated by long non-coding RNAs transcribed in both sense and antisense orientation. Recent studies present contradicting evidence for the role of small RNAs and RNase III enzyme Dicer in the X inactivation process. In this review, I discuss these results in the overall perspective of X inactivation and gene silencing.