Xenobiology: A new form of life as the ultimate biosafety tool
Version of Record online: 9 MAR 2010
Copyright © 2010 Wiley Periodicals, Inc.
Special Issue: Synthetic Biology
Volume 32, Issue 4, pages 322–331, April 2010
How to Cite
Schmidt, M. (2010), Xenobiology: A new form of life as the ultimate biosafety tool. Bioessays, 32: 322–331. doi: 10.1002/bies.200900147
- Issue online: 26 MAR 2010
- Version of Record online: 9 MAR 2010
- synthetic biology;
- xeno nucleic acids
Synthetic biologists try to engineer useful biological systems that do not exist in nature. One of their goals is to design an orthogonal chromosome different from DNA and RNA, termed XNA for xeno nucleic acids. XNA exhibits a variety of structural chemical changes relative to its natural counterparts. These changes make this novel information-storing biopolymer “invisible” to natural biological systems. The lack of cognition to the natural world, however, is seen as an opportunity to implement a genetic firewall that impedes exchange of genetic information with the natural world, which means it could be the ultimate biosafety tool. Here I discuss, why it is necessary to go ahead designing xenobiological systems like XNA and its XNA binding proteins; what the biosafety specifications should look like for this genetic enclave; which steps should be carried out to boot up the first XNA life form; and what it means for the society at large.