Prospects & Overviews
TRPM1: The endpoint of the mGluR6 signal transduction cascade in retinal ON-bipolar cells
Article first published online: 11 JUN 2010
Copyright © 2010 WILEY Periodicals, Inc.
Volume 32, Issue 7, pages 609–614, July 2010
How to Cite
Morgans, C. W., Brown, R. L. and Duvoisin, R. M. (2010), TRPM1: The endpoint of the mGluR6 signal transduction cascade in retinal ON-bipolar cells. Bioessays, 32: 609–614. doi: 10.1002/bies.200900198
- Issue published online: 28 JUN 2010
- Article first published online: 11 JUN 2010
- bipolar cell;
- metabotropic glutamate receptor;
- synaptic transmission;
- TRP channel
For almost 30 years the ion channel that initiates the ON visual pathway in vertebrate vision has remained elusive. Recent findings now indicate that the pathway, which begins with unbinding of glutamate from the metabotropic glutamate receptor 6 (mGluR6), ends with the opening of the transient receptor potential (TRP)M1 cation channel. As a component of the mGluR6 signal transduction pathway, mutations in TRPM1 would be expected to cause congenital stationary night blindness (CSNB), and several such mutations have already been identified in CSNB families. Furthermore, expression of TRPM1 in both the retina and skin raises the possibility that a genetic link exists between certain types of visual and skin disorders.