Insights & Perspectives
On the border of the homeotic function: Re-evaluating the controversial role of cofactor-recruiting motifs
The role of cofactor-recruiting motifs in conferring Hox evolutionary flexibility may critically depend on the protein environment
Version of Record online: 5 MAY 2011
Copyright © 2011 WILEY Periodicals, Inc.
Volume 33, Issue 7, pages 499–507, July 2011
How to Cite
Merabet, S. and Hudry, B. (2011), On the border of the homeotic function: Re-evaluating the controversial role of cofactor-recruiting motifs. Bioessays, 33: 499–507. doi: 10.1002/bies.201100019
- Issue online: 16 JUN 2011
- Version of Record online: 5 MAY 2011
- fushi tarazu;
In this review we present concepts that challenge a recently emerging paradigm explaining how similar Hox proteins perform different developmental functions across evolution, despite relatively limited sequence variability. This paradigm relates to the transcription factor, Fushi tarazu (Ftz), whose evolutionary plasticity has been shown to rely on the shuffling between two short protein recognition motifs. We discuss the Ftz paradigm and consider alternative interpretations to the evolutionary flexibility of this Hox protein. In particular, we propose that the protein environment might have played a critical role in the functional shuffling of Ftz during arthropod evolution.