Basophils: Important emerging players in allergic and anti-parasite responses

Authors

  • Christian Schwartz,

    1. Department of Infection Biology, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany
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  • David Voehringer

    Corresponding author
    1. Department of Infection Biology, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany
    • Department of Infection Biology, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.
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Abstract

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The recent development of transgenic mouse strains depleted in basophils has helped in elucidating the diverse functions of basophils in the primary in secondary immune responses: from acting as antigen-presenting cells and contributing to B cell activation to their role in allergic inflammation, worm expulsion and tick resistance.

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