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Keywords:

  • allergy;
  • basophils;
  • helminth;
  • Th2 cells
Thumbnail image of graphical abstract

The recent development of transgenic mouse strains depleted in basophils has helped in elucidating the diverse functions of basophils in the primary in secondary immune responses: from acting as antigen-presenting cells and contributing to B cell activation to their role in allergic inflammation, worm expulsion and tick resistance.