Prospects & Overviews
Evolution of eukaryotic genome architecture: Insights from the study of a rapidly evolving metazoan, Oikopleura dioica
Non-adaptive forces such as elevated mutation rates may influence the evolution of genome architecture
Article first published online: 17 JUN 2011
Copyright © 2011 WILEY Periodicals, Inc.
Volume 33, Issue 8, pages 592–601, August 2011
How to Cite
Chavali, S., Morais, D. A. d. L., Gough, J. and Babu, M. M. (2011), Evolution of eukaryotic genome architecture: Insights from the study of a rapidly evolving metazoan, Oikopleura dioica. Bioessays, 33: 592–601. doi: 10.1002/bies.201100034
- Issue published online: 19 JUL 2011
- Article first published online: 17 JUN 2011
- gene duplication;
- protein domains;
- tandem repeats;
- transposable elements
Recent sequencing of the metazoan Oikopleura dioica genome has provided important insights, which challenges the current understanding of eukaryotic genome evolution. Many genomic features of O. dioica show deviation from the commonly observed trends in other eukaryotic genomes. For instance, O. dioica has a rapidly evolving, highly compact genome with a divergent intron-exon organization. Additionally, O. dioica lacks the minor spliceosome and key DNA repair pathway genes. Even with a compact genome, O. dioica contains tandem repeats, comparable to other eukaryotes, and shows lineage-specific expansion of certain protein domains. Here, we review its genomic features in the context of current knowledge, discuss implications for contemporary biology and identify areas for further research. Analysis of the O. dioica genome suggests that non-adaptive forces such as elevated mutation rates might influence the evolution of genome architecture. The knowledge of unique genomic features and splicing mechanisms in O. dioica may be exploited for synthetic biology applications, such as generation of orthogonal splicing systems.