Prospects & Overviews
Proteolytic processing of the p75 neurotrophin receptor: A prerequisite for signalling?
Neuronal life, growth and death signalling are crucially regulated by intra-membrane proteolysis and trafficking of p75NTR
Article first published online: 30 JUN 2011
Copyright © 2011 WILEY Periodicals, Inc.
Volume 33, Issue 8, pages 614–625, August 2011
How to Cite
Skeldal, S., Matusica, D., Nykjaer, A. and Coulson, E. J. (2011), Proteolytic processing of the p75 neurotrophin receptor: A prerequisite for signalling?. Bioessays, 33: 614–625. doi: 10.1002/bies.201100036
- Issue published online: 19 JUL 2011
- Article first published online: 30 JUN 2011
Vol. 34, Issue 6, 521, Article first published online: 23 MAR 2012
- neuronal cell death;
- neuronal cell survival;
- Trk receptors
The common neurotrophin receptor (p75NTR) regulates various functions in the developing and adult nervous system. Cell survival, cell death, axonal and growth cone retraction, and regulation of the cell cycle can be regulated by p75NTR-mediated signals following activation by either mature or pro-neurotrophins and in combination with various co-receptors, including Trk receptors and sortilin. Here, we review the known functions of p75NTR by cell type, receptor-ligand combination, and whether regulated intra-membrane proteolysis of p75NTR is required for signalling. We highlight that the generation of the intracellular domain fragment of p75NTR is associated with many of the receptor functions, regardless of its ligand and co-receptor interactions.