Proteolytic processing of the p75 neurotrophin receptor: A prerequisite for signalling?

Neuronal life, growth and death signalling are crucially regulated by intra-membrane proteolysis and trafficking of p75NTR

Authors

  • Sune Skeldal,

    Corresponding author
    1. The Lundbeck Foundation Research Center MIND, Department of Medical Biochemistry, Aarhus University, Aarhus, Denmark
    2. Queensland Brain Institute, The University of Queensland, Brisbane, Australia
    • The Lundbeck Foundation Research Center MIND, Department of Medical Biochemistry, Aarhus University, Aarhus, Denmark.
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  • Dusan Matusica,

    1. Queensland Brain Institute, The University of Queensland, Brisbane, Australia
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  • Anders Nykjaer,

    1. The Lundbeck Foundation Research Center MIND, Department of Medical Biochemistry, Aarhus University, Aarhus, Denmark
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  • Elizabeth J. Coulson

    1. Queensland Brain Institute, The University of Queensland, Brisbane, Australia
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Errata

This article is corrected by:

  1. Errata: Proteolytic processing of the p75 neurotrophin receptor: A prerequisite for signalling? Volume 34, Issue 6, 521, Article first published online: 23 March 2012

Abstract

The common neurotrophin receptor (p75NTR) regulates various functions in the developing and adult nervous system. Cell survival, cell death, axonal and growth cone retraction, and regulation of the cell cycle can be regulated by p75NTR-mediated signals following activation by either mature or pro-neurotrophins and in combination with various co-receptors, including Trk receptors and sortilin. Here, we review the known functions of p75NTR by cell type, receptor-ligand combination, and whether regulated intra-membrane proteolysis of p75NTR is required for signalling. We highlight that the generation of the intracellular domain fragment of p75NTR is associated with many of the receptor functions, regardless of its ligand and co-receptor interactions.

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