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Towards cracking the epigenetic code using a combination of high-throughput epigenomics and quantitative mass spectrometry-based proteomics

Authors

  • Hendrik G. Stunnenberg,

    1. Nijmegen Centre for Molecular Life Sciences, Department of Molecular Biology, Radboud University Nijmegen, Nijmegen, The Netherlands
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  • Michiel Vermeulen

    Corresponding author
    1. Department of Molecular Cancer Research, University Medical Center Utrecht, Utrecht, The Netherlands
    • Department of Molecular Cancer Research, University Medical Center Utrecht, Utrecht, The Netherlands.
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Abstract

High-throughput genomic sequencing and quantitative mass spectrometry (MS)-based proteomics technology have recently emerged as powerful tools, increasing our understanding of chromatin structure and function. Both of these approaches require substantial investments and expertise in terms of instrumentation, experimental methodology, bioinformatics, and data interpretation and are, therefore, usually applied independently from each other by dedicated research groups. However, when applied reiteratively in the context of epigenetics research these approaches are strongly synergistic in nature.

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