Prospects & Overviews
The mystery of C. elegans aging: An emerging role for fat
Distant parallels between C. elegans aging and metabolic syndrome?
Version of Record online: 27 FEB 2012
Copyright © 2012 WILEY Periodicals, Inc.
Volume 34, Issue 6, pages 466–471, June 2012
How to Cite
Ackerman, D. and Gems, D. (2012), The mystery of C. elegans aging: An emerging role for fat. Bioessays, 34: 466–471. doi: 10.1002/bies.201100189
- Issue online: 21 MAY 2012
- Version of Record online: 27 FEB 2012
- C. elegans;
- metabolic syndrome
New C. elegans studies imply that lipases and lipid desaturases can mediate signaling effects on aging. But why might fat homeostasis be critical to aging? Could problems with fat handling compromise health in nematodes as they do in mammals? The study of signaling pathways that control longevity could provide the key to one of the great unsolved mysteries of biology: the mechanism of aging. But as our view of the regulatory pathways that control aging grows ever clearer, the nature of aging itself has, if anything, grown more obscure. In particular, focused investigations of the oxidative damage theory have raised questions about an old assumption: that a fundamental cause of aging is accumulation of molecular damage. Could fat dyshomeostasis instead be critical?