Insights & Perspectives
Why does the immune system of Atlantic cod lack MHC II?
Article first published online: 13 APR 2012
Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Volume 34, Issue 8, pages 648–651, August 2012
How to Cite
Star, B. and Jentoft, S. (2012), Why does the immune system of Atlantic cod lack MHC II?. Bioessays, 34: 648–651. doi: 10.1002/bies.201200005
- Issue published online: 12 JUL 2012
- Article first published online: 13 APR 2012
- Funded Access
- adaptive immunity;
- Atlantic cod;
- innate immunity;
MHC II, a major feature of the adaptive immune system, is lacking in Atlantic cod, and there are different scenarios (metabolic cost hypothesis or functional shift hypothesis) that might explain this loss. The lack of MHC II coincides with an increased number of genes for MHC I and Toll-like receptors (TLRs).