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Keywords:

  • adaptive immunity;
  • Atlantic cod;
  • genomics;
  • innate immunity;
  • MHC
Thumbnail image of graphical abstract

MHC II, a major feature of the adaptive immune system, is lacking in Atlantic cod, and there are different scenarios (metabolic cost hypothesis or functional shift hypothesis) that might explain this loss. The lack of MHC II coincides with an increased number of genes for MHC I and Toll-like receptors (TLRs).