• Open Access

Why does the immune system of Atlantic cod lack MHC II?

Authors

  • Bastiaan Star,

    Corresponding author
    1. Centre for Ecological and Evolutionary Synthesis (CEES), Department of Biology, University of Oslo, Oslo, Norway
    • Centre for Ecological and Evolutionary Synthesis (CEES), Department of Biology, University of Oslo, Oslo, Norway.
    Search for more papers by this author
  • Sissel Jentoft

    1. Centre for Ecological and Evolutionary Synthesis (CEES), Department of Biology, University of Oslo, Oslo, Norway
    Search for more papers by this author

Abstract

original image

MHC II, a major feature of the adaptive immune system, is lacking in Atlantic cod, and there are different scenarios (metabolic cost hypothesis or functional shift hypothesis) that might explain this loss. The lack of MHC II coincides with an increased number of genes for MHC I and Toll-like receptors (TLRs).

Ancillary