Prospects & Overviews
A frontier in the understanding of synaptic plasticity: Solving the structure of the postsynaptic density
Article first published online: 23 APR 2012
Copyright © 2012 WILEY Periodicals, Inc.
Volume 34, Issue 7, pages 599–608, July 2012
How to Cite
Gold, M. G. (2012), A frontier in the understanding of synaptic plasticity: Solving the structure of the postsynaptic density. Bioessays, 34: 599–608. doi: 10.1002/bies.201200009
- Issue published online: 14 JUN 2012
- Article first published online: 23 APR 2012
- Funded Access
- mass spectrometry;
- postsynaptic density;
- synaptic plasticity
The postsynaptic density (PSD) is a massive multi-protein complex whose functions include positioning signalling molecules for induction of long-term potentiation (LTP) and depression (LTD) of synaptic strength. These processes are thought to underlie memory formation. To understand how the PSD coordinates bidirectional synaptic plasticity with different synaptic activation patterns, it is necessary to determine its three-dimensional structure. A structural model of the PSD is emerging from investigation of its molecular composition and connectivity, in addition to structural studies at different levels of resolution. Technical innovations including mass spectrometry of cross-linked proteins and super-resolution light microscopy can drive progress. Integrating different information relating to PSD structure is challenging since the structure is so large and complex. The reconstruction of a PSD subcomplex anchored by AKAP79 exemplifies on a small scale how integration can be achieved. With its entire molecular structure coming into focus, this is a unique opportunity to study the PSD.