Prospects & Overviews
The genome in space and time: Does form always follow function?
How does the spatial and temporal organization of a eukaryotic genome reflect and influence its functions?
Version of Record online: 6 JUL 2012
Copyright © 2012 WILEY Periodicals, Inc.
Volume 34, Issue 9, pages 800–810, September 2012
How to Cite
Duan, Z. and Blau, C. A. (2012), The genome in space and time: Does form always follow function?. Bioessays, 34: 800–810. doi: 10.1002/bies.201200034
- Issue online: 14 AUG 2012
- Version of Record online: 6 JUL 2012
- chromosome conformation capture (3C);
- genome architecture;
- genome function;
- three-dimensional (3D) organization
Recent systematic studies using newly developed genomic approaches have revealed common mechanisms and principles that underpin the spatial organization of eukaryotic genomes and allow them to respond and adapt to diverse functional demands. Genomes harbor, interpret, and propagate genetic and epigenetic information, and the three-dimensional (3D) organization of genomes in the nucleus should be intrinsically linked to their biological functions. However, our understanding of the mechanisms underlying both the topological organization of genomes and the various nuclear processes is still largely incomplete. In this essay, we focus on the functional relevance as well as the biophysical properties of common organizational themes in genomes (e.g. looping, clustering, compartmentalization, and dynamics), and examine the interconnection between genome structure and function from this angle. Present evidence supports the idea that, in general, genome architecture reflects and influences genome function, and is relatively stable. However, the answer as to whether genome architecture is a hallmark of cell identity remains elusive.