Insights & Perspectives
A positive role for yeast extrachromosomal rDNA circles?
Extrachromosomal ribosomal DNA circle accumulation during the retrograde response may suppress mitochondrial cheats in yeast through the action of TAR1
Article first published online: 18 JUN 2012
Copyright © 2012 WILEY Periodicals, Inc.
Volume 34, Issue 9, pages 725–729, September 2012
How to Cite
Poole, A. M., Kobayashi, T. and Ganley, A. R. D. (2012), A positive role for yeast extrachromosomal rDNA circles?. Bioessays, 34: 725–729. doi: 10.1002/bies.201200037
- Issue published online: 14 AUG 2012
- Article first published online: 18 JUN 2012
- Swedish Research Council (to AMP) and JSPS. Grant Number: #19870028
- retrograde response;
- ribosomal DNA;
Yeast mitochondria frequently mutate, and some dysfunctional mitochondria out-compete wild-type versions. The retrograde response enables yeast to tolerate dysfunction, but also produces ribosomal DNA circles (ERCs). We propose that ERC accumulation increases expression of the rDNA antisense gene, TAR1, which counteracts spread of respiration-deficient mitochondria in matings with wild-type yeast.