Prospects & Overviews
HIPK2: A tumour suppressor that controls DNA damage-induced cell fate and cytokinesis
Article first published online: 21 NOV 2012
Copyright © 2013 WILEY Periodicals, Inc.
Volume 35, Issue 1, pages 55–64, January 2013
How to Cite
Hofmann, T. G., Glas, C. and Bitomsky, N. (2013), HIPK2: A tumour suppressor that controls DNA damage-induced cell fate and cytokinesis. Bioessays, 35: 55–64. doi: 10.1002/bies.201200060
- Issue published online: 12 DEC 2012
- Article first published online: 21 NOV 2012
- DNA damage;
In response to DNA-damage, cells have to decide between different cell fate programmes. Activation of the tumour suppressor HIPK2 specifies the DNA damage response (DDR) and tips the cell fate balance towards an apoptotic response. HIPK2 is activated by the checkpoint kinase ATM, and triggers apoptosis through regulatory phosphorylation of a set of cellular key molecules including the tumour suppressor p53 and the anti-apoptotic corepressor CtBP. Recent work has identified HIPK2 as a regulator of the ultimate step in cytokinesis: the abscission of the mother and daughter cells. Since proper cytokinesis is essential for genome stability and maintenance of correct ploidy, this finding sheds new light on the tumour suppressor function of HIPK2. Here we highlight the molecular mechanisms coordinating HIPK2 function and discuss its emerging role as a tumour suppressor.