These authors contributed equally.
Prospects & Overviews
The emerging biology of muscle stem cells: Implications for cell-based therapies
Article first published online: 6 AUG 2012
Copyright © 2013 WILEY Periodicals, Inc.
Special Issue: Stem Cells
Volume 35, Issue 3, pages 231–241, March 2013
How to Cite
Bentzinger, C. F., Wang, Y. X., von Maltzahn, J. and Rudnicki, M. A. (2013), The emerging biology of muscle stem cells: Implications for cell-based therapies. Bioessays, 35: 231–241. doi: 10.1002/bies.201200063
- Issue published online: 11 FEB 2013
- Article first published online: 6 AUG 2012
- Funded Access
- satellite cells;
- stem cells;
Cell-based therapies for degenerative diseases of the musculature remain on the verge of feasibility. Myogenic cells are relatively abundant, accessible, and typically harbor significant proliferative potential ex vivo. However, their use for therapeutic intervention is limited due to several critical aspects of their complex biology. Recent insights based on mouse models have advanced our understanding of the molecular mechanisms controlling the function of myogenic progenitors significantly. Moreover, the discovery of atypical myogenic cell types with the ability to cross the blood-muscle barrier has opened exciting new therapeutic avenues. In this paper, we outline the major problems that are currently associated with the manipulation of myogenic cells and discuss promising strategies to overcome these obstacles.