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Keywords:

  • ALREX;
  • intron;
  • nonsense-mediated decay;
  • 3′-UTR;
  • 5′-UTR

Abstract

Although introns in 5′- and 3′-untranslated regions (UTRs) are found in many protein coding genes, rarely are they considered distinctive entities with specific functions. Indeed, mammalian transcripts with 3′-UTR introns are often assumed nonfunctional because they are subject to elimination by nonsense-mediated decay (NMD). Nonetheless, recent findings indicate that 5′- and 3′-UTR intron status is of significant functional consequence for the regulation of mammalian genes. Therefore these features should be ignored no longer.