These authors contributed equally to this work.
Insights & Perspectives
Introns in UTRs: Why we should stop ignoring them
Article first published online: 26 OCT 2012
Copyright © 2012 WILEY Periodicals, Inc.
Volume 34, Issue 12, pages 1025–1034, December 2012
How to Cite
Bicknell, A. A., Cenik, C., Chua, H. N., Roth, F. P. and Moore, M. J. (2012), Introns in UTRs: Why we should stop ignoring them. Bioessays, 34: 1025–1034. doi: 10.1002/bies.201200073
- Issue published online: 14 NOV 2012
- Article first published online: 26 OCT 2012
- nonsense-mediated decay;
Although introns in 5′- and 3′-untranslated regions (UTRs) are found in many protein coding genes, rarely are they considered distinctive entities with specific functions. Indeed, mammalian transcripts with 3′-UTR introns are often assumed nonfunctional because they are subject to elimination by nonsense-mediated decay (NMD). Nonetheless, recent findings indicate that 5′- and 3′-UTR intron status is of significant functional consequence for the regulation of mammalian genes. Therefore these features should be ignored no longer.