Prospects & Overviews
Genome instability: Does genetic diversity amplification drive tumorigenesis?
Article first published online: 5 SEP 2012
Copyright © 2012 WILEY Periodicals, Inc.
Volume 34, Issue 11, pages 963–972, November 2012
How to Cite
Lane, A. B. and Clarke, D. J. (2012), Genome instability: Does genetic diversity amplification drive tumorigenesis?. Bioessays, 34: 963–972. doi: 10.1002/bies.201200082
- Issue published online: 12 OCT 2012
- Article first published online: 5 SEP 2012
- complex chromosome rearrangements;
- DNA replication;
Recent data show that catastrophic events during one cell cycle can cause massive genome damage producing viable clones with unstable genomes. This is in contrast with the traditional view that tumorigenesis requires a long-term process in which mutations gradually accumulate over decades. These sudden events are likely to result in a large increase in genomic diversity within a relatively short time, providing the opportunity for selective advantages to be gained by a subset of cells within a population. This genetic diversity amplification, arising from a single aberrant cell cycle, may drive a population conversion from benign to malignant. However, there is likely a period of relative genome stability during the clonal expansion of tumors – this may provide an opportunity for therapeutic intervention, especially if mechanisms that limit tolerance of aneuploidy are exploited.