Prospects & Overviews
Stem cells of the respiratory system: From identification to differentiation into functional epithelium
Article first published online: 22 NOV 2012
Copyright © 2013 WILEY Periodicals, Inc.
Special Issue: Stem Cells
Volume 35, Issue 3, pages 261–270, March 2013
How to Cite
Green, M. D., Huang, S. X.L. and Snoeck, H.-W. (2013), Stem cells of the respiratory system: From identification to differentiation into functional epithelium. Bioessays, 35: 261–270. doi: 10.1002/bies.201200090
- Issue published online: 11 FEB 2013
- Article first published online: 22 NOV 2012
- pluripotent stem cells;
- postnatal stem cells;
- tissue engineering
We review recent progress in the stem cell biology of the respiratory system, and discuss its scientific and translational ramifications. Several studies have defined novel stem cells in postnatal lung and airways and implicated their roles in tissue homeostasis and repair. In addition, significant advances in the generation of respiratory epithelium from pluripotent stem cells (PSCs) now provide a novel and powerful platform for understanding lung development, modeling pulmonary diseases, and implementing drug screening. Finally, breakthroughs have been made in the generation of decellularized lung matrices that can serve as a scaffold for repopulation with respiratory cells derived from either postnatal or PSCs. These studies are a critical step forward towards the still distant goal of stem cell-based regenerative medicine for diseases of lung and airways.