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The metastatic cancer cell cortex: An adaptation to enhance robust cell division in novel environments?
Article first published online: 20 SEP 2012
DOI: 10.1002/bies.201200109
Copyright © 2012 WILEY Periodicals, Inc.
Additional Information
How to Cite
Matthews, H. K. and Baum, B. (2012), The metastatic cancer cell cortex: An adaptation to enhance robust cell division in novel environments?. Bioessays, 34: 1017–1020. doi: 10.1002/bies.201200109
Publication History
- Issue published online: 14 NOV 2012
- Article first published online: 20 SEP 2012
- Abstract
- Article
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Keywords:
- actin;
- cancer;
- metastasis;
- mitosis
To metastasize, cancer cells must be able to complete cell division in environments very different from their tissue of origin. We suggest that mitotic cell rounding, aided by several actin-regulatory oncogenes, may facilitate this process in a robust, context-independent manner.