Prospects & Overviews
Synthetic polymers and their potential as genetic materials
Article first published online: 27 DEC 2012
Copyright © 2013 WILEY Periodicals, Inc.
Volume 35, Issue 2, pages 113–122, February 2013
How to Cite
Pinheiro, V. B., Loakes, D. and Holliger, P. (2013), Synthetic polymers and their potential as genetic materials. Bioessays, 35: 113–122. doi: 10.1002/bies.201200135
- Issue published online: 15 JAN 2013
- Article first published online: 27 DEC 2012
- central dogma;
- expanded genetic alphabet;
- genetic information;
- synthetic genetic polymers;
DNA and RNA are the only known natural genetic materials. Systematic modification of each of their chemical building blocks (nucleobase, sugar, and phosphate) has enabled the study of the key properties that make those nucleic acids genetic materials. All three moieties contribute to replication and, significantly, all three moieties can be replaced by synthetic analogs without loss of function. Synthetic nucleic acid polymers capable of storing and propagating information not only expand the central dogma, but also highlight that DNA and RNA are not unique chemical solutions for genetic information storage. By considering replication as a question of information transfer, we propose that any polymer that can be replicated could serve as a genetic material.
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