Epithelial cell translocation: New insights into mechanisms of tumor initiation

Authors

  • Cheuk T. Leung

    Corresponding author
    1. Department of Cell Biology, Harvard Medical School, Boston, MA, USA
    Current affiliation:
    1. Department of Pharmacology, University of Minnesota Medical School, Minneapolis, MN, USA
    • Department of Cell Biology, Harvard Medical School, Boston, MA, USA
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Abstract

original image

A cell translocation mechanism displaces sporadic mutant cells from normal, suppressive epithelial environment during early steps of tumor initiation. This epithelial cell translocation process exerts a selective pressure on early mutant cells to survive and grow in new microenvironment outside of their native niches.

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