SEARCH

SEARCH BY CITATION

Keywords:

  • epithelial tissue;
  • organotypic culture;
  • tissue homeostasis;
  • tumorigenesis;
  • tumor initiation
Thumbnail image of graphical abstract

A cell translocation mechanism displaces sporadic mutant cells from normal, suppressive epithelial environment during early steps of tumor initiation. This epithelial cell translocation process exerts a selective pressure on early mutant cells to survive and grow in new microenvironment outside of their native niches.