Insights & Perspectives
Epithelial cell translocation: New insights into mechanisms of tumor initiation
Article first published online: 19 DEC 2012
Copyright © 2013 WILEY Periodicals, Inc.
Volume 35, Issue 2, pages 80–83, February 2013
How to Cite
Leung, C. T. (2013), Epithelial cell translocation: New insights into mechanisms of tumor initiation. Bioessays, 35: 80–83. doi: 10.1002/bies.201200151
- Issue published online: 15 JAN 2013
- Article first published online: 19 DEC 2012
- epithelial tissue;
- organotypic culture;
- tissue homeostasis;
- tumor initiation
A cell translocation mechanism displaces sporadic mutant cells from normal, suppressive epithelial environment during early steps of tumor initiation. This epithelial cell translocation process exerts a selective pressure on early mutant cells to survive and grow in new microenvironment outside of their native niches.