Prospects & Overviews
Late endosomal and lysosomal trafficking during integrin-mediated cell migration and invasion
Cell matrix receptors are trafficked through the late endosomal pathway in a way that dictates how cells migrate
Article first published online: 22 APR 2013
© 2013 WILEY Periodicals, Inc.
Volume 35, Issue 6, pages 523–532, June 2013
How to Cite
Rainero, E. and Norman, J. C. (2013), Late endosomal and lysosomal trafficking during integrin-mediated cell migration and invasion. Bioessays, 35: 523–532. doi: 10.1002/bies.201200160
- Issue published online: 15 MAY 2013
- Article first published online: 22 APR 2013
- cell migration;
- late endosome;
Recently it has become clear that trafficking of integrins to late endosomes is key to the regulation of integrin expression and function during cell migration. Here we discuss the molecular machinery that dictates whether integrins are sorted to recycling endosomes or are targeted to late endosomes and lysosomes. Integrins and other receptors that are sorted to late endosomes are not necessarily degraded and, under certain circumstances, can be spared destruction and returned to the cell surface to drive cell migration and invasion. We will discuss how the exchange of adhesion receptors and other key regulators of cell migration between late endosomes/lysosomes and the plasma membrane can promote dynamic turnover of adhesions during cell migration.