These authors contributed equally to this work.
Prospects & Overviews
Phosphatidylinositol 4,5-bisphosphate: Targeted production and signaling
Version of Record online: 10 APR 2013
© 2013 WILEY Periodicals, Inc.
Volume 35, Issue 6, pages 513–522, June 2013
How to Cite
Sun, Y., Thapa, N., Hedman, A. C. and Anderson, R. A. (2013), Phosphatidylinositol 4,5-bisphosphate: Targeted production and signaling. Bioessays, 35: 513–522. doi: 10.1002/bies.201200171
- Issue online: 15 MAY 2013
- Version of Record online: 10 APR 2013
- NIH. Grant Number: CA104708
- lipid messenger;
- phosphatidylinositol 4,5-bisphosphate;
- phosphatidylinositol phosphate kinase;
- PI4,5P2 effector
Phosphatidylinositol 4,5-bisphosphate (PI4,5P2) is a key lipid signaling molecule that regulates a vast array of biological activities. PI4,5P2 can act directly as a messenger or can be utilized as a precursor to generate other messengers: inositol trisphosphate, diacylglycerol, or phosphatidylinositol 3,4,5-trisphosphate. PI4,5P2 interacts with hundreds of different effector proteins. The enormous diversity of PI4,5P2 effector proteins and the spatio-temporal control of PI4,5P2 generation allow PI4,5P2 signaling to control a broad spectrum of cellular functions. PI4,5P2 is synthesized by phosphatidylinositol phosphate kinases (PIPKs). The array of PIPKs in cells enables their targeting to specific subcellular compartments through interactions with targeting factors that are often PI4,5P2 effectors. These interactions are a mechanism to define spatial and temporal PI4,5P2 synthesis and the specificity of PI4,5P2 signaling. In turn, the regulation of PI4,5P2 effectors at specific cellular compartments has implications for understanding how PI4,5P2 controls cellular processes and its role in diseases.