If microbial ecosystem therapy can change your life, what's the problem?

Authors

  • Grace Ettinger,

    1. Human Microbiology and Probiotics, Lawson Health Research Institute, The University of Western Ontario, London, Ontario, Canada
    2. Department of Microbiology & Immunology, The University of Western Ontario, London, Ontario, Canada
    Search for more papers by this author
  • Jeremy P. Burton,

    1. Human Microbiology and Probiotics, Lawson Health Research Institute, The University of Western Ontario, London, Ontario, Canada
    2. Department of Surgery, The University of Western Ontario, London, Ontario, Canada
    Search for more papers by this author
  • Gregor Reid

    Corresponding author
    1. Human Microbiology and Probiotics, Lawson Health Research Institute, The University of Western Ontario, London, Ontario, Canada
    2. Department of Microbiology & Immunology, The University of Western Ontario, London, Ontario, Canada
    3. Department of Surgery, The University of Western Ontario, London, Ontario, Canada
    Search for more papers by this author

Abstract

The increased incidence of morbidity and mortality due to Clostridium difficile infection, had led to the emergence of fecal microbial transplantation (FMT) as a highly successful treatment. From this, a 32 strain stool substitute has been derived, and successfully tested in a pilot human study. These approaches could revolutionize not only medical care of infectious diseases, but potentially many other conditions linked to the human microbiome. But a second revolution may be needed in order for regulatory agencies, society and medical practitioners to accept and utilize these interventions, monitor their long term effects, have a degree of control over their use, or at a minimum provide guidelines for donors and recipients.

Ancillary