Insights & Perspectives
Enlightening the brain: Linking deep brain photoreception with behavior and physiology
Article first published online: 26 MAY 2013
© 2013 WILEY Periodicals, Inc.
Volume 35, Issue 9, pages 775–779, September 2013
How to Cite
Fernandes, A. M., Fero, K., Driever, W. and Burgess, H. A. (2013), Enlightening the brain: Linking deep brain photoreception with behavior and physiology. Bioessays, 35: 775–779. doi: 10.1002/bies.201300034
- Issue published online: 14 AUG 2013
- Article first published online: 26 MAY 2013
- Intramural Research Program of the National Institute of Child Health and Human Development (H.A.B.)
- deep brain photoreceptors;
Vertebrates respond to light with more than just their eyes. In this article, we speculate on the intriguing possibility that a link remains between non-visual opsins and neurohormonal systems that control neuronal circuit formation and activity in mammals. Historically, the retina and pineal gland were considered the only significant light-sensing tissues in vertebrates. However over the last century, evidence has accumulated arguing that extra-ocular tissues in vertebrates influence behavior through non-image-forming photoreception. One such class of extra-ocular light detectors are the long mysterious deep brain photoreceptors. Here, we review recent findings on the cellular identity and the function of deep brain photoreceptors controlling behavior and physiology in zebrafish, and discuss their implications.