Prospects & Overviews
Segmental folding of chromosomes: A basis for structural and regulatory chromosomal neighborhoods?
Article first published online: 5 JUL 2013
© 2013 The Authors. Bioessays published by WILEY Periodicals, Inc.
Volume 35, Issue 9, pages 818–828, September 2013
How to Cite
Nora, E. P., Dekker, J. and Heard, E. (2013), Segmental folding of chromosomes: A basis for structural and regulatory chromosomal neighborhoods?. Bioessays, 35: 818–828. doi: 10.1002/bies.201300040
- Issue published online: 14 AUG 2013
- Article first published online: 5 JUL 2013
- chromatin domains;
- chromatin folding;
- chromosome conformation capture (3C);
- long-range transcriptional regulation;
- regulatory landscapes;
- topologically associating chromosome domains
We discuss here a series of testable hypotheses concerning the role of chromosome folding into topologically associating domains (TADs). Several lines of evidence suggest that segmental packaging of chromosomal neighborhoods may underlie features of chromatin that span large domains, such as heterochromatin blocks, association with the nuclear lamina and replication timing. By defining which DNA elements preferentially contact each other, the segmentation of chromosomes into TADs may also underlie many properties of long-range transcriptional regulation. Several observations suggest that TADs can indeed provide a structural basis to regulatory landscapes, by controlling enhancer sharing and allocation. We also discuss how TADs may shape the evolution of chromosomes, by causing maintenance of synteny over large chromosomal segments. Finally we suggest a series of experiments to challenge these ideas and provide concrete examples illustrating how they could be practically applied.