Get access

Retroviruses facilitate the rapid evolution of the mammalian placenta

Authors

Errata

This article is corrected by:

  1. Errata: Corrigendum Volume 36, Issue 8, 807, Article first published online: 4 June 2014

Corresponding author:

Edward B. Chuong

E-mail: echuong@stanford.edu

Abstract

The mammalian placenta exhibits elevated expression of endogenous retroviruses (ERVs), but the evolutionary significance of this feature remains unclear. I propose that ERV-mediated regulatory evolution was, and continues to be, an important mechanism underlying the evolution of placental development. Many recent studies have focused on the co-option of ERV-derived genes for specific functional adaptations in the placenta. However, the co-option of ERV-derived regulatory elements could potentially lead to the incorporation of entire gene regulatory networks, which, I argue, would facilitate relatively rapid developmental evolution of the placenta. I suggest a model in which an ancient retroviral infection led to the establishment of the ancestral placental developmental gene network through the co-option of ERV-derived regulatory elements. Consequently, placental development would require elevated tolerance to ERV activity. This in turn would expose a continuous stream of novel ERV mutations that may have catalyzed the developmental diversification of the mammalian placenta.

Get access to the full text of this article

Ancillary