Prospects & Overviews
Multiple actions of Lucilia sericata larvae in hard-to-heal wounds
Larval secretions contain molecules that accelerate wound healing, reduce chronic inflammation and inhibit bacterial infection
Article first published online: 7 OCT 2013
© 2013 WILEY Periodicals, Inc.
Volume 35, Issue 12, pages 1083–1092, December 2013
How to Cite
Cazander, G., Pritchard, D. I., Nigam, Y., Jung, W. and Nibbering, P. H. (2013), Multiple actions of Lucilia sericata larvae in hard-to-heal wounds. Bioessays, 35: 1083–1092. doi: 10.1002/bies.201300071
- Issue published online: 18 NOV 2013
- Article first published online: 7 OCT 2013
- larval therapy;
- Lucilia sericata;
In Europe ≈15,000 patients receive larval therapy for wound treatment annually. Over the past few years, clinical studies have demonstrated the success of larvae of Lucilia sericata as debridement agents. This is based on a combination of physical and biochemical actions. Laboratory investigations have advanced our understanding of the biochemical mechanisms underlying the beneficial effects of larval secretions, including removal of dead tissue, reduction of the bacterial burden, and promotion of tissue regeneration. The present article summarizes our current understanding of the microbiological, immunological, and wound healing actions of larval therapy, and the molecules involved in these beneficial effects. Future studies will focus on the isolation, identification, and (pre)clinical testing of the effective molecules of L. sericata larvae. These molecules may be candidates for the development of new agents for the treatment of several infectious and inflammatory diseases, including chronic wounds.