Prospects & Overviews
Major depressive disorder: A loss of circadian synchrony?
Article first published online: 3 SEP 2013
© 2013 WILEY Periodicals, Inc.
Volume 35, Issue 11, pages 940–944, November 2013
How to Cite
Edgar, N. and McClung, C. A. (2013), Major depressive disorder: A loss of circadian synchrony?. Bioessays, 35: 940–944. doi: 10.1002/bies.201300086
- Issue published online: 11 OCT 2013
- Article first published online: 3 SEP 2013
- circadian rhythms;
Circadian rhythms in the sleep/wake cycle, along with a range of physiological measures, are severely disrupted in individuals with major depressive disorder (MDD). Moreover, several central circadian genes have been implicated as potential genetic factors underlying the illness through candidate gene studies and some genome wide association studies. However, investigations into the molecular underpinnings of circadian disturbances in the human brain have been quite challenging. In their recent publication, Li and colleagues have used a novel approach to determine the rhythmic patterns of circadian gene expression in several regions of the human brain, and how these patterns are disrupted in MDD. Their findings demonstrate that in healthy subjects, several brain regions outside the suprachiasmatic nucleus (the master clock) exhibit diurnal gene expression patterns that are disrupted in the brains of MDD subjects. These findings will provide the foundation for future studies of gene-specific drug targets, and biomarkers for the disease.