Prospects & Overviews
3′UTRs take a long shot in the brain
Article first published online: 20 SEP 2013
© 2014 WILEY Periodicals, Inc.
Volume 36, Issue 1, pages 39–45, January 2014
How to Cite
Wang, L. and Yi, R. (2014), 3′UTRs take a long shot in the brain. Bioessays, 36: 39–45. doi: 10.1002/bies.201300100
- Issue published online: 10 DEC 2013
- Article first published online: 20 SEP 2013
- NIH/NIAMS. Grant Number: R01AR059697
- American Cancer Society. Grant Number: RSG-13-197-01-DDC
- NIH Predoctoral Training. Grant Number: T32 GM08759
- RNP aggregates;
The fast advancing RNA-seq technology has unveiled an unexpected diversity and expression specificity of 3′ untranslated regions (3′UTRs) of mRNAs. In particular, neural mRNAs seem to express significantly longer 3′UTRs, some of which are over 10 kb in length. The extensive elongation of 3′UTRs in neural tissues provides intriguing possibilities for cell type-specific regulations that are governed by miRNAs, RNA-binding proteins and ribonucleoprotein aggregates. In this article, we review recent progress in the characterization of mRNA 3′UTRs and discuss their implications in the understanding of 3′UTR-mediated gene regulation.