RNA's role in genome rearrangement. Ciliated protists, such as Oxytricha, shown, have two types of nuclei that differentiate from each other. Development in these microbial eukaryotes provides a paragon for studies of genome remodeling, with extensive use of non-coding RNAs. On pages 84–87 of this issue, Wenwen Fang and Laura Landweber discuss how RNA-guided processes of genome rearrangement or repair could influence other eukaryotes. Cover by Wenyi Fang. SEM images courtesy of Robert Hammersmith.