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The various consequences of jumping: How mammalian transposons can differentially influence gene expression and function. Transposable elements (TEs) make up a large fraction of mammalian genomes. On pages 397–407, Akagi, Li and Symer discuss how these elements can exert wide-ranging biological impacts by variably affecting and disrupting gene expression, regulation, structure and function. Both germline and somatic mobilization of TEs can occur, potentially contributing to genetic diversity both between individuals in mammalian populations, and within individuals' tissues and cells. The authors discuss various factors that can influence the wide-ranging functional impacts of ongoing, endogenous transposition in mammals.

Cover art by Anthony Baker (Medical Visuals, Health Sciences Library, The Ohio State University).