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Functional genomics and bioinformatics
Protein-interaction mapping in search of effective drug targets
Article first published online: 17 AUG 2005
DOI: 10.1002/bies.20284
Copyright © 2005 Wiley Periodicals, Inc.
Additional Information
How to Cite
Chaudhuri, A. and Chant, J. (2005), Protein-interaction mapping in search of effective drug targets. Bioessays, 27: 958–969. doi: 10.1002/bies.20284
Publication History
- Issue published online: 17 AUG 2005
- Article first published online: 17 AUG 2005
- Abstract
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Abstract
Signaling complexes and networks are being intensely studied in an attempt to discover pathways that are amenable to therapeutic intervention. A challenge in this search is to understand the effect that the modulation of a target will have on the overall function of a cell and its surrounding neighbors. Protein-interaction mapping reveals relationships between proteins and their impact on cellular processes and is being used more widely in our understanding of disease mechanisms and their treatment. The review discusses challenges and breakthroughs in this new and evolving area and its impact on medicine. BioEssays 27:958–969, 2005. © 2005 Wiley Periodicals, Inc.