Problems and paradigms
Fundamental issues in systems biology
Version of Record online: 18 NOV 2005
Copyright © 2005 Wiley Periodicals, Inc.
Volume 27, Issue 12, pages 1270–1276, December 2005
How to Cite
O'Malley, M. A. and Dupré, J. (2005), Fundamental issues in systems biology. Bioessays, 27: 1270–1276. doi: 10.1002/bies.20323
- Issue online: 18 NOV 2005
- Version of Record online: 18 NOV 2005
- We gratefully acknowledge research support from the Economic and Social Research Council (ESRC), UK, and Overseas Conference Funding from the British Academy
In the context of scientists' reflections on genomics, we examine some fundamental issues in the emerging postgenomic discipline of systems biology. Systems biology is best understood as consisting of two streams. One, which we shall call ‘pragmatic systems biology’, emphasises large-scale molecular interactions; the other, which we shall refer to as ‘systems-theoretic biology’, emphasises system principles. Both are committed to mathematical modelling, and both lack a clear account of what biological systems are. We discuss the underlying issues in identifying systems and how causality operates at different levels of organisation. We suggest that resolving such basic problems is a key task for successful systems biology, and that philosophers could contribute to its realisation. We conclude with an argument for more sociologically informed collaboration between scientists and philosophers. BioEssays 27:1270–1276, 2005. © 2005 Wiley Periodicals, Inc.