This article is a US government work and, as such, is in the public domain in the United States of America.
What the papers say
Telomerase: not just for the elongation of telomeres†
Article first published online: 24 JAN 2006
Copyright © 2006 Wiley Periodicals, Inc.
Volume 28, Issue 2, pages 109–112, February 2006
How to Cite
Calado, R. T. and Chen, J. (2006), Telomerase: not just for the elongation of telomeres. Bioessays, 28: 109–112. doi: 10.1002/bies.20365
- Issue published online: 24 JAN 2006
- Article first published online: 24 JAN 2006
Telomerase RNA component (TERC) and telomerase reverse transcriptase (TERT) function together to elongate telomeres and to protect chromosomal ends. Recent studies have discovered that overexpression of telomerase's TERT subunit promoted epidermal stem-cell mobilization, hair growth and stem-cell proliferation without changes in length of telomeres.1,2 This telomerase functional characteristic is TERC independent and is operated through a mechanism other than telomere elongation. These findings open new doors for future explorations to understand telomerase function and its interaction with other cell components in the regulation of cell senescence and tumorigenesis. BioEssays 28: 109–112, 2006. © 2006 Wiley periodicals, Inc.