From genes to aggressive behavior: the role of serotonergic system
Article first published online: 13 APR 2006
Copyright © 2006 Wiley Periodicals, Inc.
Volume 28, Issue 5, pages 495–503, May 2006
How to Cite
Popova, N. K. (2006), From genes to aggressive behavior: the role of serotonergic system. Bioessays, 28: 495–503. doi: 10.1002/bies.20412
- Issue published online: 13 APR 2006
- Article first published online: 13 APR 2006
- this research is supported by Russian Foundation for Basic Research, grant 05-04-48124, SBRAN Integration Program, and grant for Leading Russian Scientific Schools
Recent investigations in neurogenomics have opened up new lines of research into a crucial genetic problem—the pathway from genes to behavior. This paper concentrates on the involvement of protein elements in the brain neurotransmitter serotonin (5-HT) system in the genetic control of aggressive behavior. Specifically, it describes: (1) the effect of the knockout of MAO A, the principal enzyme in 5-HT degradation, (2) the association of intermale aggression with the polymorphism in the Tph2 gene encoding the key enzyme in 5-HT synthesis in the brain, tryptophan hydroxylase (TPH), and (3) the effect of selective breeding for nonaggressive behavior on 5-HT metabolism, TPH activity and 5-HT1A receptors in the brain. The review provides converging lines of evidence that: (1) brain 5-HT contributes to a critical mechanism underlying genetically defined individual differences in aggressiveness, and (2) genes encoding pivotal enzymes in 5-HT metabolism (TPH and MAO A), 5-HT-transporter, 5-HT1A and 5-HT1B receptors belong to a group of genes that modulate aggressive behavior. BioEssays 28: 495–503, 2006. © 2006 Wiley Periodicals, Inc.