GTP-binding proteins of the Rho/Rac family: regulation, effectors and functions in vivo

Authors

  • Xosé R. Bustelo,

    Corresponding author
    1. Centro de Investigación del Cáncer and Instituto de Biología Molecular y Celular del Cáncer (IBMCC), CSIC-University of Salamanca, Salamanca, Spain
    • Centro de Investigación del Cáncer and Instituto de Biología Molecular y Celular del Cáncer (IBMCC). CSIC-University of Salamanca, Campus Unamuno, E-37007 Salamanca, Spain.
    Search for more papers by this author
  • Vincent Sauzeau,

    1. Centro de Investigación del Cáncer and Instituto de Biología Molecular y Celular del Cáncer (IBMCC), CSIC-University of Salamanca, Salamanca, Spain
    Search for more papers by this author
  • Inmaculada M. Berenjeno

    1. Centro de Investigación del Cáncer and Instituto de Biología Molecular y Celular del Cáncer (IBMCC), CSIC-University of Salamanca, Salamanca, Spain
    Search for more papers by this author

Abstract

Rho/Rac proteins constitute a subgroup of the Ras superfamily of GTP hydrolases. Although originally implicated in the control of cytoskeletal events, it is currently known that these GTPases coordinate diverse cellular functions, including cell polarity, vesicular trafficking, the cell cycle and transcriptomal dynamics. In this review, we will provide an overview on the recent advances in this field regarding the mechanism of regulation and signaling, and the roles in vivo of this important GTPase family. BioEssays 29:356–370, 2007. © 2007 Wiley Periodicals, Inc.

Ancillary