The diverse functions of Krüppel-like factors 4 and 5 in epithelial biology and pathobiology
Article first published online: 16 MAY 2007
Copyright © 2007 Wiley Periodicals, Inc.
Volume 29, Issue 6, pages 549–557, June 2007
How to Cite
McConnell, B. B., Ghaleb, A. M., Nandan, M. O. and Yang, V. W. (2007), The diverse functions of Krüppel-like factors 4 and 5 in epithelial biology and pathobiology. Bioessays, 29: 549–557. doi: 10.1002/bies.20581
- Issue published online: 16 MAY 2007
- Article first published online: 16 MAY 2007
- National Institutes of Health. Grant Numbers: DK52230, DK64399, CA84197
The Krüppel-like factors (KLFs) comprise a family of evolutionarily conserved zinc finger transcription factors that regulate numerous biological processes including proliferation, differentiation, development and apoptosis. KLF4 and KLF5 are two closely related members of this family and are both highly expressed in epithelial tissues. In the intestinal epithelium, KLF4 is expressed in terminally differentiated epithelial cells at the villus borders of the mucosa and inhibits cell growth, while KLF5 is expressed in proliferating epithelial cells at the base of the intestinal crypts and promotes cell growth. KLF4 and KLF5 respond to a myriad of external stress stimuli and are likely involved in restoring cellular homeostasis following exposure to stressors. Confirming their importance in maintaining tissue integrity, KLF4 and KLF5 are both dysregulated in various types of cancer. Here we review the recent advances in defining the physiological and pathobiological roles of KLF4 and KLF5, focusing on their functions in the intestinal epithelium. BioEssays 29:549–557, 2007. © 2007 Wiley Periodicals, Inc.