The collagen family members as cell adhesion proteins
Version of Record online: 17 SEP 2007
Copyright © 2007 Wiley Periodicals, Inc.
Volume 29, Issue 10, pages 1001–1010, October 2007
How to Cite
Heino, J. (2007), The collagen family members as cell adhesion proteins. Bioessays, 29: 1001–1010. doi: 10.1002/bies.20636
- Issue online: 17 SEP 2007
- Version of Record online: 17 SEP 2007
The collagen family of extracellular matrix proteins has played a fundamental role in the evolution of multicellular animals. At the present, 28 triple helical proteins have been named as collagens and they can be divided into several subgroups based on their structural and functional properties. In tissues, the cells are anchored to collagenous structures. Often the interaction is indirect and mediated by matrix glycoproteins, but cells also express receptors, which have the ability to directly bind to the triple helical domains in collagens. Some receptors bind to sites that are abundant in all collagens. However, increasing evidence indicates that the coevolution of collagens and cell adhesion mechanisms has given rise to receptors that bind to specific motifs in collagens. These receptors may also recognize the different members of the large collagen family in a selective manner. This review summarizes the present knowledge about the properties of collagen subtypes as cell adhesion proteins. BioEssays 29:1001–1010, 2007. © 2007 Wiley Periodicals, Inc.