What the papers say

Damage-induced reactivation of cohesin in postreplicative DNA repair

  1. Alexander R. Ball Jr,
  2. Kyoko Yokomori*

Article first published online: 14 DEC 2007

DOI: 10.1002/bies.20691

Issue

BioEssays

BioEssays

Volume 30, Issue 1, pages 5–9, January 2008

Additional Information

How to Cite

Ball, A. R. and Yokomori, K. (2008), Damage-induced reactivation of cohesin in postreplicative DNA repair. Bioessays, 30: 5–9. doi: 10.1002/bies.20691

Author Information

  1. Department of Biological Chemistry, School of Medicine, University of California, Irvine, CA

*240D Med Sci I, Department of Biological Chemistry, School of Medicine, University of California, Irvine, CA 92697-1700.

Publication History

  1. Issue published online: 14 DEC 2007
  2. Article first published online: 14 DEC 2007

Funded by

  • The work in the Yokomori laboratory was supported by grants from the NIH CA100710 and the DOD BCRP (DAMD17-03-1-0436) to K. Y

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Abstract

Cohesin establishes sister-chromatid cohesion during S phase to ensure proper chromosome segregation in mitosis. It also facilitates postreplicative homologous recombination repair of DNA double-strand breaks by promoting local pairing of damaged and intact sister chromatids. In G2 phase, cohesin that is not bound to chromatin is inactivated, but its reactivation can occur in response to DNA damage. Recent papers by Koshland's and Sjögren's groups describe the critical role of the known cohesin cofactor Eco1 (Ctf7) and ATR checkpoint kinase in damage-induced reactivation of cohesin, revealing an intricate mechanism that regulates sister-chromatid pairing to maintain genome integrity.1,2 BioEssays 30:5–9, 2008. © 2007 Wiley Periodicals, Inc.

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