Vertebrate JIP3 orthologues in Drosophila and C. elegans are Syd and UNC-16 respectively. The vertebrate JIP1 orthologue in Drosophila is APLIP1. MAPKKK family members are vertebrate DLK, vertebrate MLK, vertebrate MEKK1, Drosophila Wnd and C. elegans JKK-1. The vertebrate MKK orthologue is Drosophila Hep and the vertebrate JNK3 orthologues are respectively Drosophila Bsk and C. elegans JNK-1.
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What the papers say
“JIP”ing along the axon: the complex roles of JIPs in axonal transport†
Article first published online: 14 DEC 2007
DOI: 10.1002/bies.20695
Copyright © 2007 Wiley Periodicals, Inc.
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How to Cite
Koushika, S. P. (2008), “JIP”ing along the axon: the complex roles of JIPs in axonal transport. Bioessays, 30: 10–14. doi: 10.1002/bies.20695
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Publication History
- Issue published online: 14 DEC 2007
- Article first published online: 14 DEC 2007
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- Work in the SPK laboratory is supported by a grant from Department of Science and Technology, India
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Abstract
JIPs are JNK interacting proteins and bind to JNK cascade kinases. JIP1 and JIP3 were known to be adaptors linking cargo to Kinesin-I, a major molecular motor for axonal transport. Recent research sheds further light on JIPs' complex roles in axonal transport, namely in activation of Kinesin-I and in cargo release. In Drosophila, APLIP1/JIP1 allows the Kinesin-I complex to enable cargo release through activation of JNK signaling.1 In mammalian cell culture, JIP1 is necessary and, together with UNC-76/FEZ1, sufficient for activating Kinesin-I.2 I discuss and compare the many roles played by JIP1 and JIP3 through interactions with several distinct players, in retrograde as well as anterograde transport. BioEssays 30:10–14, 2008. © 2007 Wiley Periodicals, Inc.