What the papers say
Losing B cell identity
Article first published online: 21 FEB 2008
Copyright © 2008 Wiley Periodicals, Inc.
Volume 30, Issue 3, pages 203–207, March 2008
How to Cite
Carotta, S. and Nutt, S. L. (2008), Losing B cell identity. Bioessays, 30: 203–207. doi: 10.1002/bies.20725
- Issue published online: 21 FEB 2008
- Article first published online: 21 FEB 2008
- Pfizer Australia Research Fellowship and the National Health and Medical Research Council of Australia
- Australian Research Council
The transcription factor Pax5 is essential for the initial commitment of hematopoietic progenitors to the B cell lineage. Recently, our understanding of the lineage commitment process has been extended with the finding that Pax5 is also continuously required throughout B cell development to reinforce commitment, as inactivation of Pax5 in mature B cells results in their de-differentiation to a progenitor stage that is capable of multi-lineage potential.1 The reliance of B cell identity on a single gene is not without its problems as the loss of Pax5 results in B cell malignancies in mouse models and mutation in human PAX5 is the most-common genetic lesion in acute lymphoblastic leukemia. BioEssays 30:203–207, 2008. © 2008 Wiley Periodicals, Inc.