Review Article

Edited GluR2, a gatekeeper for motor neurone survival?

  1. S.D. Buckingham1,
  2. S. Kwak2,
  3. A.K. Jones1,
  4. S.E. Blackshaw3,
  5. D.B. Sattelle1,*

Article first published online: 20 OCT 2008

DOI: 10.1002/bies.20836

Issue

BioEssays

BioEssays

Volume 30, Issue 11-12, pages 1185–1192, November - December 2008

Additional Information

How to Cite

Buckingham, S.D., Kwak, S., Jones, A.K., Blackshaw, S.E. and Sattelle, D.B. (2008), Edited GluR2, a gatekeeper for motor neurone survival?. Bioessays, 30: 1185–1192. doi: 10.1002/bies.20836

Author Information

  1. 1

    MRC Functional Genomics Unit, Department of Physiology Anatomy and Genetics, University of Oxford, South Parks Road, Oxford OX1 3QX, UK

  2. 2

    Department of Neurology, Graduate School of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan

  3. 3

    Department of Physiology Anatomy and Genetics, University of Oxford, South Parks Road, Oxford OX1 3QX, UK

*MRC Functional Genomics Unit, Department of Physiology Anatomy and Genetics, University of Oxford, South Parks Road, Oxford OX1 3QX, UK.

Publication History

  1. Issue published online: 20 OCT 2008
  2. Article first published online: 20 OCT 2008

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Abstract

Amyotrophic lateral sclerosis (ALS) is a progressive degenerative disorder of motor neurones. Although the genetic basis of familial forms of ALS has been well explored, the molecular basis of sporadic ALS is less well understood. Recent evidence has linked sporadic ALS with the failure to edit key residues in ionotropic glutamate receptors, resulting in excessive influx of calcium ions into motor neurones which in turn triggers cell death. Here we suggest that edited AMPA glutamate (GluR2) receptor subunits serve as gatekeepers for motor neurone survival. BioEssays 30:1185–1192, 2008. © 2008 Wiley Periodicals, Inc.

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