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Review Article
The role of the ubiquitin proteasome system in synapse remodeling and neurodegenerative diseases
Article first published online: 20 OCT 2008
DOI: 10.1002/bies.20843
Copyright © 2008 Wiley Periodicals, Inc.
1521-1878/asset/cover.gif?v=1&s=f234907c8865cfc8a1848f6eb81952e44c16f2af "BioEssays")
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How to Cite
Ding, M. and Shen, K. (2008), The role of the ubiquitin proteasome system in synapse remodeling and neurodegenerative diseases. Bioessays, 30: 1075–1083. doi: 10.1002/bies.20843
Publication History
- Issue published online: 20 OCT 2008
- Article first published online: 20 OCT 2008
- Abstract
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Abstract
The ubiquitin proteasome system is a potent regulatory mechanism used to control protein stability in numerous cellular processes, including neural development. Many neurodegenerative diseases are featured by the accumulation of UPS-associated proteins, suggesting the UPS dysfunction may be crucial for pathogenesis. Recent experiments have highlighted the UPS as a key player during synaptic development. Here we summarize recent discoveries centered on the role of the UPS in synapse remodeling and draw attention to the potential link between the synaptic UPS dysfunction and the pathology of neurodegenerative diseases. BioEssays 30:1075–1083, 2008. © 2008 Wiley Periodicals, Inc.