Cover Photograph: Confocal microscopy image of a section of a chicken heart showing a developing coronary vessel and the surrounding myocardium. The section was immunolabeled for Tbx5 (shown in green), Pdlim7 (shown in red), and counter-stained with DAPI to show nuclei (blue). In cells of the left ventricle, Tbx5 revealed exclusive nuclear localization as seen in the upper right corner. However, when co-expressed with Pdlim7 in cells of a coronary vessel, Tbx5 is localized to the cytoplasm. PDZ-LIM proteins, the family to which Pdlim7 belongs, function in skeletal and cardiac muscle organization and maintenance by stabilizing the actin cytoskeleton and regulating cell adhesion via their interactions with α-actinin and integrins, respectively. Pdlim7 turns out also to be crucial for valve formation in the developing zebrafish heart. See the review “Nucleo-cytoplasmic functions of the PDZ-LIM protein family: new insights in organ development” by Krcmery, Camarata, Kulisz and Simon in this issue.