Man-Sun Kim, Jeong-Rae Kim and Kwang-Hyun Cho
Article first published online: 18 MAY 2010 | DOI: 10.1002/bies.201090019
Cover Photograph: Resolving developmental genetics in the fourth dimension: an illustration (by Kwang-Hyun Cho himself) of the principle of dynamic network motifs in Drosophila development. Hitherto largely considered in terms of time-invariant networks, drosophila development is viewed in the article by Man-Sun Kim, Jeong-Rae Kim, and Kwang-Hyun Cho as the result of networks of gene interactions that change during the course of development. Using this paradigm, pivotal developmental events can be correlated with particular changes from one constellation of gene interactions to a different one, and the method allows the identification of certain network motifs that are not identifiable using static approaches. Features article: “Dynamic network rewiring determines temporal regulatory functions in the Drosophila melanogaster development processes”, see pages 505 – 513.